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August 9, 2017

New stem cell-based implant offers a ‘functional cure’ for Type 1 diabetes

by John_A

Why it matters to you

For decades, treating diabetes has been a highly involved and difficult process. Stem cells could change all that.

We barely recovered from the excitement of editing human embryos in the U.S. but now the miracle of science has given us another reason to gape. Last week, two individuals with Type 1 diabetes received implants derived from embryonic stem cells in order to treat their chronic condition. This marks the first time that such an approach has been taken to curing diabetes.

The new implants, known as PEC-Direct from Viacyte, are expected to release inulin when patients’ blood sugar levels rise, thereby returning them to normal levels. The immune systems of Type 1 diabetes patients attack insulin-producing cells in the pancreas, resulting in abnormally low levels of the crucial hormone. While doctors and scientists have long searched for a way to replenish insulin in the human body (often with stem cells), they have been unsuccessful so far.

An implant, however, could be the answer. Scientists designed the new device to automatically release the hormone when it is needed, which allows stem cells to otherwise mature in the body while they are unneeded.

“If successful, this strategy could really change the way we treat Type 1 diabetes in the future,” Emily Burns of the charity Diabetes U.K said. This is actually comparable to another treatment method, in which pancreas cells from organ donors are introduced into patients’ bodies. However, given the lack of donors available, this is often not the most dependable of solutions.

Stem cells address this problem, as they can be produced in essentially infinite amounts.

“A limitless source of human insulin-producing cells would be a major step forward on the journey to a potential cure for diabetes,” said James Shapiro at the University of Alberta, Canada, one of the pioneers of the original donor pancreas method. “For sure, this will, in the end, prove to be a durable landmark for progress in diabetes care.”

Ultimately, we still have to determine whether or not this will prove completely successful in treating diabetes. It is also worth pointing out that this stem cell approach would be considered a functional cure. As Paul Laikind of Viacyte explained, “It’s not truly a cure because we wouldn’t address the autoimmune cause of the disease, but we would be replacing the missing cells.” But no matter what you call it, it certainly looks like a step in the right direction.




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