Skip to content

May 28, 2016

New algorithm performs complex DNA origami

by John_A

Researchers from MIT, Arizona State University and Baylor University have developed a new algorithm that promises to simplify the arduous and complex task of assembling DNA into structures other than a double helix. These structures could eventually be used as everything from DNA storage modules to delivery vehicles for CRISPR enzymes and other medicines, but until now the process of creating them has been prohibitive.

Rather than starting from scratch and sequencing thousands of DNA base pairs by hand — a process that only a few experts know how to do at this point — the new process called DNA Origami Sequencing flips that around and starts with a geometric shape. A user simply plugs the desired shape into the algorithm, and the computer will determine the order of base pairs needed to twist and fold the DNA into that shape. As long as the shape fits certain parameters, the computer does all the work.

The algorithm, which gets the slick name “DAEDALUS” could have uses beyond medicine as well. For starters, it will make the processes behind DNA data storage much cheaper, but according to MIT associate professor Mark Bathe, the DAEDALUS algorithm could do for DNA sequencing what 3D printing did for macroscopic modeling.

Read more from News

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Note: HTML is allowed. Your email address will never be published.

Subscribe to comments

%d bloggers like this: